28-amino-acid neuropeptide researched for immune regulation, neuroprotection, and circadian rhythm modulation.
Peptigrity tracks VIP (Vasoactive Intestinal Peptide) across 219 shops with 28 independent lab tests and an average HPLC purity of 99.39%.
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide from the secretin/glucagon superfamily that signals through 2 G-protein-coupled receptors: VPAC1 (immune cells, liver, lung) and VPAC2 (smooth muscle, CNS, pancreas). Both receptors elevate intracellular cAMP, producing anti-inflammatory and vasodilatory effects. VIP is one of the most potent endogenous inducers of regulatory T cells (Tregs), suppressing Th1/Th17 pathways while promoting Th2/Treg responses — a mechanism relevant to autoimmune disease, transplant tolerance, and neuroinflammation research. In the hypothalamus, VIP regulates prolactin secretion and circadian clock signaling. In the pineal gland, VIP stimulates melatonin synthesis through cAMP/cGMP pathways. Plasma half-life is approximately 1–2 minutes due to rapid endopeptidase degradation, driving research into stabilized analogs. Molecular weight: approximately 3,326.8 Da.
Every submitted test helps the community verify purity across brands. Free, fast, independent.