KPV

<!-- form-tracked-clarification --> Peptigrity tracks the free tripeptide form of KPV (Lys-Pro-Val) sold by research peptide vendors. An acetylated-amidated derivative (Ac-KPV-NH₂) exists in finished wellness products such as oral sprays and topical serums, but those are not currently in our test database. <!-- /form-tracked-clarification -->

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) that retains potent anti-inflammatory activity without the pigmentation effects of the parent hormone. The primary mechanism involves direct inhibition of NF-κB nuclear translocation by blocking the importin-α3/p65 interaction, suppressing pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. In 2 murine models of inflammatory bowel disease (DSS colitis and CD45RBhi transfer colitis), KPV reduced colonic inflammation and accelerated body weight recovery, including in MC1R-deficient mice — indicating the anti-inflammatory effect operates at least partially independent of melanocortin receptor signaling. KPV also upregulates tight junction proteins (occludin, claudin, ZO-1) to strengthen epithelial barrier integrity in gut and skin tissue. Molecular weight: approximately 341.4 Da.