Neuroprotective octapeptide from ADNP researched for microtubule stabilization and cognitive preservation.
Peptigrity tracks Adamax (Davunetide/NAP) across 219 shops with 4 independent lab tests and an average HPLC purity of 99.71%.
Adamax (also known as Davunetide or NAP) is an 8-amino-acid neuroprotective peptide (sequence: NAPVSIPQ) derived from activity-dependent neuroprotective protein (ADNP), a VIP-responsive gene product essential for brain development. The primary mechanism involves stabilization of microtubule dynamics through interaction with tubulin and microtubule-associated proteins (MAPs), protecting axonal transport, synaptic integrity, and neuronal morphology against tau hyperphosphorylation, amyloid-β toxicity, and oxidative damage. Allon Therapeutics conducted Phase 2/3 clinical trials for progressive supranuclear palsy (PSP) — primary endpoints were not met, but the compound demonstrated favorable safety and tolerability with human pharmacokinetic data confirming CNS bioavailability via intranasal delivery. Two proline residues (positions 3 and 7) contribute to conformational stability. Molecular weight: approximately 824.9 Da.
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