An anti-inflammatory cosmetic peptide (trade name Rigin) derived from an antibody fragment — it suppresses the cytokine interleukin-6 to reduce the inflammation-driven collagen breakdown of "inflammaging", and is one of the two peptides in Matrixyl 3000.
Last Updated: July 2026
Palmitoyl Tetrapeptide-7 (INCI; trade name Rigin; also Pal-GQPR) is a topical cosmetic peptide — a four-amino-acid sequence (Gly-Gln-Pro-Arg) derived from the constant region of immunoglobulin G, with a palmitoyl chain for skin penetration. Unlike the collagen-stimulating matrikines, it works on the anti-inflammatory side, and is one of the two peptides in the Matrixyl 3000 blend. It is a cosmetic ingredient, not an approved drug.
It suppresses the overproduction of interleukin-6 (IL-6) and related pro-inflammatory cytokines — the low-grade inflammation of "inflammaging" that both reduces fibroblast collagen synthesis and drives MMP breakdown of the extracellular matrix — so by damping IL-6 it addresses the degradation side of the collagen balance. This is the complement to a synthesis-stimulating peptide like palmitoyl tripeptide-1, which is why the two are paired in Matrixyl 3000.
The mechanistic and in-vitro rationale (IL-6 suppression, reduced inflammatory ECM degradation) is coherent, but as with most cosmetic peptides the isolated clinical evidence is limited and much of the finished-product data comes from the Matrixyl 3000 blend and its manufacturer — so expect a modest, supportive, anti-inflammatory contribution rather than a dramatic standalone effect. Evidence level: In-vitro/mechanistic; isolated clinical data limited; effect modest.
Palmitoyl tetrapeptide-7 is well tolerated in topical use; sold as a raw peptide for formulation, HPLC purity and mass-spec identity confirm the correct Pal-GQPR at the labeled amount. Peptigrity buys the raw peptide anonymously, tests it at independent ISO-accredited labs, and publishes the unedited COA; the trust score weights lab purity and reviews equally (50/50). See how to read lab results.
Educational information only; not medical or skincare advice. Palmitoyl Tetrapeptide-7 is a cosmetic ingredient, not an approved drug — patch-test before use. Peptigrity does not sell, endorse, or recommend products or vendors.
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