2-peptide research blend in one vial: Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7. Sederma's second-generation anti-aging peptide blend — pairing a collagen-signaling peptide (palmitoyl tripeptide-1) with an anti-inflammatory one (palmitoyl tetrapeptide-7) to address both collagen synthesis and its inflammatory breakdown.
Also known as: Palmitoyl Tripeptide-1 / Palmitoyl Tetrapeptide-7 blend
A blend has one whole-vial purity, but the number that decides what you're holding is the net content of each component — an HPLC run resolves a separate peak for each. So we verify Matrixyl 3000 component by component. Each links to its own compound page, where its full independent testing lives.
| Component | Typical mg | Role in the blend | Verified purity | |
|---|---|---|---|---|
| Palmitoyl Tripeptide-1 | varies | Collagen (I, III, IV) and fibronectin synthesis signalling | — · 0 tests | View testing → |
| Palmitoyl Tetrapeptide-7 | varies | IL-6 suppression — limits inflammatory ECM degradation | — · 0 tests | View testing → |
Composition varies by vendor. The components above are consistent across shops, but the milligrams and ratio are not — always dose by the individual component amounts printed on your vial, never by a generic “blend dose.”
A blend is the single hardest product to trust — the whole-vial purity tells you the material is clean, but not whether every peptide is present in the right amount. Two questions decide that, and both are answerable in a lab.
Mass spec (or a clean HPLC peak per compound) confirms each peptide is in the vial — not one short, not a cheaper substitute standing in for the expensive one.
Tested milligrams vs. labelled milligrams, per component. This is where blends fail quietly — one component underdosed to pad margin while the vial still “contains” everything.
Tests run on a Matrixyl 3000 vial as sold — broken down per component. This is the data no shop and no competitor publishes.
Matrixyl 3000 is new to the library. Have a COA for a Matrixyl 3000 vial? Add it — every submission maps back to the 2 component compounds automatically.
Submit a Matrixyl 3000 lab testUntil more Matrixyl 3000 vials are tested, the strongest signal is how each component performs in single-compound testing across the shops we track. Tap any card for its full data.
Last Updated: July 2026
Matrixyl 3000 is a trademarked Sederma peptide blend — not a single molecule. It combines two palmitoylated signal peptides: palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR), both of which have their own Peptigrity profiles. It's the second-generation successor to the original Matrixyl (a single, different peptide), and is one of the most common peptide complexes in anti-aging skincare. It is a cosmetic ingredient, not an approved drug.
The blend targets both sides of the collagen balance: palmitoyl tripeptide-1 (Pal-GHK), a palmitoylated GHK matrikine, signals fibroblasts to build collagen (I, III, IV) and fibronectin, while palmitoyl tetrapeptide-7 (Pal-GQPR) is an anti-inflammatory peptide that suppresses interleukin-6 — a cytokine that both lowers collagen synthesis and drives MMP breakdown of the matrix. In other words, one peptide stimulates synthesis while the other blunts inflammatory degradation, which is the rationale for combining them.
In-vitro evidence for collagen stimulation is solid, and cosmetic studies report periorbital wrinkle reduction — but this is the key honesty point: much of the widely quoted efficacy figure traces to the manufacturer (Sederma) rather than independent journals, and the independent clinical base is smaller than the marketing implies. A commonly cited study (Robinson, ~23 women, 60 days, 3% formulation) reported statistically significant reductions in wrinkle area and depth versus vehicle. Treat headline percentages critically and expect a modest, supportive effect. Evidence level: In-vitro solid; clinical base smaller and more manufacturer-associated than marketing suggests.
Matrixyl 3000 is well tolerated in topical use, and the crucial distinction is compositional: original Matrixyl is a single peptide (Pal-KTTKS), while Matrixyl 3000 is the two-peptide (Pal-Tripeptide-1 + Pal-Tetrapeptide-7) blend — to tell which is in a product, read the INCI list. Products marketed simply as "Matrixyl" may contain either, so the INCI declaration is what matters.
Because Matrixyl 3000 is a blend, the relevant checks are whether both component peptides are present, correctly identified, and at appropriate ratios/purity — HPLC and mass-spec against the two INCI components are the objective test. Peptigrity buys the raw material anonymously, tests it at independent ISO-accredited labs, and publishes the unedited COA; the trust score weights lab purity and reviews equally (50/50). See how to read lab results.
Educational information only; not medical or skincare advice. Matrixyl 3000 is a cosmetic ingredient blend, not an approved drug — patch-test before use. Peptigrity does not sell, endorse, or recommend products or vendors.
In a blend you can only set the dose of one component — the rest follow the fixed ratio. Our calculator does that math so you don't underdose the peptide you actually care about.
Enter each component's milligrams and your BAC water — get per-component units for one syringe draw.
Open the blend calculator →How much bacteriostatic water, mixing without shaking, storage, and shelf life once mixed.
Read the reconstitution guide →It is a blend of two peptides — palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR). The INCI list names both separately.
They're different formulations, not simply better/worse — original Matrixyl (Pal-KTTKS) has stronger independent evidence; Matrixyl 3000 adds an anti-inflammatory second peptide but leans more on supplier data.
In-vitro collagen data are solid and cosmetic studies are positive, but much of the headline figure is manufacturer-derived — expect a modest, supportive effect.
No — it is a cosmetic ingredient blend used in topical skincare.
No. Peptigrity is an independent review platform, not a skincare or medical authority.