Modified growth hormone-releasing hormone (GHRH) analog for pulsatile GH release. Also known as Mod GRF (1-29). Shorter half-life than the DAC version.
Last Updated: May 2026
CJC-1295 without DAC is a modified GHRH(1-29) analog with four amino acid substitutions for enhanced enzymatic stability. It is functionally identical to mod GRF 1-29 — the names refer to the same compound. The "without DAC" designation distinguishes it from the longer-acting CJC-1295 with DAC, which adds an albumin-binding tether for 6–8 day half-life. CJC-1295 without DAC is not approved for any medical indication and is sold as a research-use-only compound.
CJC-1295 without DAC is sermorelin (GHRH(1-29)) with four amino acid substitutions — D-Ala at position 2, Gln at position 8, Ala at position 15, Leu at position 27 — that confer resistance to DPP-4 degradation and enhance binding stability. The result is a moderately extended half-life (~30 minutes) compared to native sermorelin (~10–20 min) while preserving GHRH receptor agonist activity. It produces pulsatile GH release similar to native GHRH, supporting multiple-daily-dose research protocols. Evidence level: Preclinical and Phase 1 PK; no published Phase 2/3 efficacy trials in any indication.
Phase 1 pharmacokinetic studies confirm dose-dependent GH and IGF-1 elevation with subcutaneous administration, with peak GH response at approximately 1 hour and return to baseline by 3–4 hours. No published Phase 2 or Phase 3 efficacy trials for any indication exist as of May 2026. The compound is essentially identical to mod GRF 1-29 in pharmacological terms; the dual-naming convention persists in research-grade catalogs largely for historical reasons. Evidence level: Phase 1 PK; no Phase 2/3 efficacy data.
The two compounds share the same GHRH(1-29) sequence with the four stability substitutions; CJC-1295 with DAC adds a maleimidopropionic acid (DAC) tether that covalently binds to serum albumin, extending half-life from ~30 minutes to ~6–8 days. This produces very different dosing strategies and GH-release dynamics.
| Variant | Stability modifications | Albumin tether | Half-life | GH pulse pattern |
|---|---|---|---|---|
| CJC-1295 without DAC | 4 amino acid substitutions | No | ~30 min | Discrete pulses per dose |
| CJC-1295 with DAC | 4 amino acid substitutions | Yes (DAC tether) | ~6–8 days | Sustained elevation |
| Sermorelin | None (native GHRH(1-29)) | No | ~10–20 min | Discrete pulses, shorter |
| Mod GRF 1-29 | Identical to CJC-1295 no-DAC | No | ~30 min | Discrete pulses per dose |
Side effects in available Phase 1 data and community-reported research use are mild — injection-site reactions, occasional transient flushing, mild headache. The pulsatile GH-release pattern means cortisol and prolactin effects are minimal (it is a pure GHRH analog, not a ghrelin-receptor GHS). IGF-1 elevation is dose-dependent and reversible with discontinuation. Long-term safety at sustained research-use dosing is not well-characterized given the absence of completed long-duration trials. Evidence level: Phase 1 safety data; long-term unestablished.
CJC-1295 without DAC is not approved for any medical indication anywhere in the world as of May 2026. It is sold strictly as a research-use-only compound by third-party laboratories. No active clinical development program is currently advancing. Regulatory context in are peptides legal regulatory status by country.
Because the compound is one of the most widely-sold research-grade GHRH analogs and quality variance across vendors is substantial — and because mod GRF 1-29 and CJC-1295 without DAC are the same molecule sold under different names, buyers should verify they're getting the correct compound regardless of which label the vendor uses. Independent HPLC purity testing and mass spectrometry identity confirmation are the meaningful purity signals. Guidance in how-to-test-peptides hub.
Peptigrity purchases CJC-1295 without DAC vials anonymously at standard customer pricing, sends them to ISO-accredited third-party labs for HPLC and mass spectrometry analysis, and publishes the unedited certificate of analysis. The lab test table above this section shows the cross-shop dataset. Tests come from labs including Janoshik Analytical, Freedom Diagnostics, and Chromate. Methodology in how we calculate trust scores.
Yes. CJC-1295 without DAC and mod GRF 1-29 are the same compound — GHRH(1-29) with four amino acid substitutions for stability. The dual-naming convention persists in research-grade catalogs for historical reasons. Buyers should not pay for "stacking" both names.
CJC-1295 without DAC is legal to purchase as a research chemical for laboratory use in most jurisdictions, but it is not approved for human consumption. Country breakdown in peptide legal status guide.
Independent third-party HPLC certificate of analysis from a lab the vendor does not own or pay, with mass spectrometry identity confirmation. Expected molecular weight for CJC-1295 without DAC is 3,367.8 Da. COA interpretation in red flags in peptide certificates of analysis.
Different mechanisms — CJC-1295 without DAC is a GHRH analog (acts on GHRH receptor), ipamorelin is a ghrelin-receptor agonist (acts on GHS-R1a). They engage different pituitary signaling pathways and are commonly studied in combination in research protocols to amplify GH release through complementary mechanisms.
No active clinical development program exists as of May 2026. FDA approval is unlikely without a renewed development effort.
No. CJC-1295 without DAC is not approved for human consumption and Peptigrity is an independent review platform, not a medical authority. Research-use dosing in community protocols varies widely. Anyone considering use should consult a licensed physician.
This section is for educational and informational purposes only and does not constitute medical advice. CJC-1295 without DAC is not approved by the FDA or any other regulator for human use. Always consult a qualified healthcare provider before using any peptide or research compound. Peptigrity is an independent review platform and does not sell, endorse, or recommend specific products or vendors.
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